Drug interactions
Lisuride + Promethazine
Severity: Moderate
Lisuride and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisuride is a dopamine agonist, whereas promethazine has dopamine D2 receptor blocking activity, so promethazine may reduce the therapeutic effect of lisuride in Parkinson disease or hyperprolactinemia. Sedation may also be additive.
What this interaction means in plain words
Lisuride and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid promethazine in patients taking dopamine agonists for Parkinson disease; use domperidone or another non-central antiemetic if needed, and monitor symptom control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Lisuride with Promethazine?
MediHelp rates the interaction as moderate. Lisuride and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisuride is a dopamine agonist, whereas promethazine has dopamine D2 receptor blocking activity, so promethazine may reduce the therapeutic effect of lisuride in Parkinson disease or hyperprolactinemia. Sedation may also be additive.
How serious is the interaction between Lisuride and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid promethazine in patients taking dopamine agonists for Parkinson disease; use domperidone or another non-central antiemetic if needed, and monitor symptom control.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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