Drug interactions
Lithium + Lofexidine
Severity: Moderate
Lithium and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine causes bradycardia, hypotension and QT prolongation. Lithium may contribute to conduction and repolarization abnormalities, so the combination may increase arrhythmia risk.
What this interaction means in plain words
Lithium and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and heart rate.
What to do
Check ECG at baseline and monitor heart rate, blood pressure and electrolytes. Avoid in patients with congenital long QT or significant bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lithium with Lofexidine?
MediHelp rates the interaction as moderate. Lithium and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine causes bradycardia, hypotension and QT prolongation. Lithium may contribute to conduction and repolarization abnormalities, so the combination may increase arrhythmia risk.
How serious is the interaction between Lithium and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and monitor heart rate, blood pressure and electrolytes. Avoid in patients with congenital long QT or significant bradycardia.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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