Drug interactions
Lithium + Moexipril
Severity: Major
Lithium and Moexipril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can raise serum lithium concentrations and cause lithium toxicity, including tremor, confusion, ataxia and renal effects. Onset may be delayed by weeks and the risk is higher with dehydration, renal impairment or older age.
What this interaction means in plain words
Lithium and Moexipril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lithium belongs to Central Nervous System; Moexipril belongs to Cardiovascular.
Why it happens
Reduced renal lithium clearance due to sodium depletion and altered renal hemodynamics, increasing proximal tubular lithium reabsorption.
What to do
Avoid if possible; otherwise measure lithium levels before and within the first weeks after starting moexipril and after dose changes. Reduce the lithium dose as needed and counsel on toxicity symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Moexipril?
MediHelp rates the interaction as major. Lithium and Moexipril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors can raise serum lithium concentrations and cause lithium toxicity, including tremor, confusion, ataxia and renal effects. Onset may be delayed by weeks and the risk is higher with dehydration, renal impairment or older age.
How serious is the interaction between Lithium and Moexipril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise measure lithium levels before and within the first weeks after starting moexipril and after dose changes. Reduce the lithium dose as needed and counsel on toxicity symptoms.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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