Drug interactions
Lithium + Pasireotide
Severity: Moderate
Lithium and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide is associated with QT prolongation and bradycardia, and lithium can also affect cardiac conduction and repolarization. Taken together they may increase the risk of arrhythmia.
What this interaction means in plain words
Lithium and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Pasireotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization; pasireotide also causes bradycardia.
What to do
Perform a baseline ECG and monitor it during treatment, and correct hypokalemia and hypomagnesemia before and during therapy. Monitor lithium levels and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Lithium with Pasireotide?
MediHelp rates the interaction as moderate. Lithium and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide is associated with QT prolongation and bradycardia, and lithium can also affect cardiac conduction and repolarization. Taken together they may increase the risk of arrhythmia.
How serious is the interaction between Lithium and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and monitor it during treatment, and correct hypokalemia and hypomagnesemia before and during therapy. Monitor lithium levels and heart rate.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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