Drug interactions
Lithium + Selpercatinib
Severity: Moderate
Lithium and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and lithium may add to this effect. The combination may raise the risk of ventricular arrhythmias, particularly with electrolyte disturbance or heart disease.
What this interaction means in plain words
Lithium and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Selpercatinib belongs to Oncology.
Why it happens
Additive QTc prolongation.
What to do
Obtain a baseline ECG and monitor it periodically, and correct electrolytes. Reduce or withhold selpercatinib per labeling if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Selpercatinib
Frequently asked questions
Can I take Lithium with Selpercatinib?
MediHelp rates the interaction as moderate. Lithium and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, and lithium may add to this effect. The combination may raise the risk of ventricular arrhythmias, particularly with electrolyte disturbance or heart disease.
How serious is the interaction between Lithium and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and correct electrolytes. Reduce or withhold selpercatinib per labeling if QTc becomes markedly prolonged.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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