Drug interactions
Lithium + Trandolapril
Severity: Major
Lithium and Trandolapril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can raise serum lithium concentrations and have caused lithium toxicity, sometimes severe. The risk is higher in older patients, those with renal impairment or volume depletion, and soon after starting the ACE inhibitor.
What this interaction means in plain words
Lithium and Trandolapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lithium belongs to Central Nervous System; Trandolapril belongs to Cardiovascular.
Why it happens
Reduced renal lithium clearance, likely from sodium loss and decreased glomerular filtration with increased proximal tubular reabsorption.
What to do
If the combination is necessary, check lithium levels within the first week or so of starting or changing the ACE inhibitor and regularly afterward. Reduce the lithium dose as needed and watch for tremor, confusion and gastrointestinal symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Trandolapril?
MediHelp rates the interaction as major. Lithium and Trandolapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors can raise serum lithium concentrations and have caused lithium toxicity, sometimes severe. The risk is higher in older patients, those with renal impairment or volume depletion, and soon after starting the ACE inhibitor.
How serious is the interaction between Lithium and Trandolapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is necessary, check lithium levels within the first week or so of starting or changing the ACE inhibitor and regularly afterward. Reduce the lithium dose as needed and watch for tremor, confusion and gastrointestinal symptoms.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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