Drug interactions
Lithium + Zuranolone
Severity: Moderate
Lithium and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes marked somnolence and impaired psychomotor performance, which may add to the CNS effects of lithium. This can affect driving and daily functioning.
What this interaction means in plain words
Lithium and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression; zuranolone is a positive modulator of GABA-A receptors.
What to do
Counsel on drowsiness and advise against driving for at least 12 hours after each dose. Consider a zuranolone dose reduction if CNS depressant effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Lithium with Zuranolone?
MediHelp rates the interaction as moderate. Lithium and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes marked somnolence and impaired psychomotor performance, which may add to the CNS effects of lithium. This can affect driving and daily functioning.
How serious is the interaction between Lithium and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and advise against driving for at least 12 hours after each dose. Consider a zuranolone dose reduction if CNS depressant effects are troublesome.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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