Drug interactions
Lofepramine + Lofexidine
Severity: Moderate
Lofepramine and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant that may add to lofexidine sedation and could weaken its blood pressure lowering effect. Tricyclics can also affect cardiac conduction and repolarization.
What this interaction means in plain words
Lofepramine and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedation, with possible antagonism of alpha-2 agonist effects by tricyclic antidepressants.
What to do
Monitor sedation, blood pressure, heart rate and ECG, and watch for reduced lofexidine effect on withdrawal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lofepramine and Lofexidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofepramine with Lofexidine?
MediHelp rates the interaction as moderate. Lofepramine and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant that may add to lofexidine sedation and could weaken its blood pressure lowering effect. Tricyclics can also affect cardiac conduction and repolarization.
How serious is the interaction between Lofepramine and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure, heart rate and ECG, and watch for reduced lofexidine effect on withdrawal symptoms.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
