Drug interactions
Lofepramine + Morphine
Severity: Moderate
Lofepramine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic antidepressant, adds sedation to morphine and may worsen opioid-related CNS depression. Serotonergic toxicity is possible but less likely with morphine than with other opioids.
What this interaction means in plain words
Lofepramine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with a minor theoretical serotonergic contribution.
What to do
Start with lower doses and monitor for sedation, respiratory depression and signs of serotonin toxicity such as clonus, agitation or hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Lofepramine with Morphine?
MediHelp rates the interaction as moderate. Lofepramine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine, a tricyclic antidepressant, adds sedation to morphine and may worsen opioid-related CNS depression. Serotonergic toxicity is possible but less likely with morphine than with other opioids.
How serious is the interaction between Lofepramine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower doses and monitor for sedation, respiratory depression and signs of serotonin toxicity such as clonus, agitation or hyperthermia.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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