Drug interactions
Lofepramine + Oxazepam
Severity: Moderate
Lofepramine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with some sedative properties, and combining it with a benzodiazepine can increase drowsiness and impair psychomotor performance. The effect is generally modest but relevant in older adults.
What this interaction means in plain words
Lofepramine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A enhancement and antihistaminic/anticholinergic tricyclic effects.
What to do
Start with low doses and monitor for sedation and falls. Advise caution with driving and review the need for both drugs regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Lofepramine with Oxazepam?
MediHelp rates the interaction as moderate. Lofepramine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with some sedative properties, and combining it with a benzodiazepine can increase drowsiness and impair psychomotor performance. The effect is generally modest but relevant in older adults.
How serious is the interaction between Lofepramine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for sedation and falls. Advise caution with driving and review the need for both drugs regularly.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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