Drug interactions
Lofepramine + Pseudoephedrine
Severity: Moderate
Lofepramine and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants interfere with uptake of indirect sympathomimetics and enhance noradrenergic signaling. Lofepramine can therefore produce unpredictable pressor responses, including hypertension and tachycardia, with pseudoephedrine.
What this interaction means in plain words
Lofepramine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Norepinephrine reuptake inhibition altering sympathomimetic uptake and potentiating receptor stimulation.
What to do
Monitor blood pressure and heart rate, and consider non-sympathomimetic decongestants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Lofepramine with Pseudoephedrine?
MediHelp rates the interaction as moderate. Lofepramine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants interfere with uptake of indirect sympathomimetics and enhance noradrenergic signaling. Lofepramine can therefore produce unpredictable pressor responses, including hypertension and tachycardia, with pseudoephedrine.
How serious is the interaction between Lofepramine and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and consider non-sympathomimetic decongestants.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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