Drug interactions
Lofepramine + Rocuronium
Severity: Minor
Lofepramine and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with weak anticholinergic activity. A meaningful effect on rocuronium blockade is unlikely, though additive anticholinergic or arrhythmic effects are theoretically possible perioperatively.
What this interaction means in plain words
Lofepramine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak anticholinergic activity; no established effect on nicotinic neuromuscular blockade.
What to do
No dose change is needed; monitor ECG and heart rate during anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rocuronium
Frequently asked questions
Can I take Lofepramine with Rocuronium?
MediHelp rates the interaction as minor. Lofepramine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lofepramine is a tricyclic antidepressant with weak anticholinergic activity. A meaningful effect on rocuronium blockade is unlikely, though additive anticholinergic or arrhythmic effects are theoretically possible perioperatively.
How serious is the interaction between Lofepramine and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor ECG and heart rate during anesthesia.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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