Drug interactions
Lofepramine + Salmeterol
Severity: Moderate
Lofepramine and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of sympathomimetic agents. Salmeterol is a long-acting beta-agonist, and combined use may increase heart rate, arrhythmia risk and QT prolongation. The risk is greater in patients with heart disease or low potassium.
What this interaction means in plain words
Lofepramine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic and QT-prolonging effects; tricyclics may enhance the vascular and cardiac responses to beta-agonists.
What to do
Monitor heart rate, rhythm and potassium, and consider an ECG in patients with cardiac risk factors. Use the lowest effective salmeterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Lofepramine with Salmeterol?
MediHelp rates the interaction as moderate. Lofepramine and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of sympathomimetic agents. Salmeterol is a long-acting beta-agonist, and combined use may increase heart rate, arrhythmia risk and QT prolongation. The risk is greater in patients with heart disease or low potassium.
How serious is the interaction between Lofepramine and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and potassium, and consider an ECG in patients with cardiac risk factors. Use the lowest effective salmeterol dose.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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