Drug interactions
Lofepramine + Scopolamine
Severity: Moderate
Lofepramine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with anticholinergic activity, though less than some others, and it adds to scopolamine's antimuscarinic effects. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
What this interaction means in plain words
Lofepramine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic adverse effects, especially in older patients or those with glaucoma or prostatic hypertrophy, and reduce the anticholinergic burden where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Lofepramine with Scopolamine?
MediHelp rates the interaction as moderate. Lofepramine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with anticholinergic activity, though less than some others, and it adds to scopolamine's antimuscarinic effects. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
How serious is the interaction between Lofepramine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in older patients or those with glaucoma or prostatic hypertrophy, and reduce the anticholinergic burden where possible.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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