Drug interactions
Lofepramine + Tolterodine
Severity: Moderate
Lofepramine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic with anticholinergic properties, so it adds to tolterodine's antimuscarinic effects. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion, and both drugs can affect QT.
What this interaction means in plain words
Lofepramine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, with possible additive QT prolongation.
What to do
Monitor for anticholinergic toxicity, particularly in older patients, and reduce doses or choose an alternative if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Lofepramine with Tolterodine?
MediHelp rates the interaction as moderate. Lofepramine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic with anticholinergic properties, so it adds to tolterodine's antimuscarinic effects. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion, and both drugs can affect QT.
How serious is the interaction between Lofepramine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly in older patients, and reduce doses or choose an alternative if symptomatic.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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