Drug interactions
Lofexidine + Lormetazepam
Severity: Moderate
Lofexidine and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lormetazepam is a benzodiazepine hypnotic and combined with lofexidine can cause additive sedation, dizziness and low blood pressure. Impaired alertness and falls are most likely in older or frail patients.
What this interaction means in plain words
Lofexidine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and central alpha-2 agonism.
What to do
Monitor sedation and blood pressure and use the lowest effective lormetazepam dose. Counsel patients to avoid driving or hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Lormetazepam?
MediHelp rates the interaction as moderate. Lofexidine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lormetazepam is a benzodiazepine hypnotic and combined with lofexidine can cause additive sedation, dizziness and low blood pressure. Impaired alertness and falls are most likely in older or frail patients.
How serious is the interaction between Lofexidine and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure and use the lowest effective lormetazepam dose. Counsel patients to avoid driving or hazardous tasks.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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