Drug interactions
Lofexidine + Meprobamate
Severity: Moderate
Lofexidine and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic that depresses the central nervous system, and lofexidine is itself sedating. Their combination can cause excessive drowsiness, dizziness and psychomotor impairment.
What this interaction means in plain words
Lofexidine and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through alpha-2 agonism and GABA-A-related sedative action.
What to do
Monitor for oversedation and hypotension and consider lowering the meprobamate dose. Warn the patient against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Meprobamate?
MediHelp rates the interaction as moderate. Lofexidine and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic that depresses the central nervous system, and lofexidine is itself sedating. Their combination can cause excessive drowsiness, dizziness and psychomotor impairment.
How serious is the interaction between Lofexidine and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and hypotension and consider lowering the meprobamate dose. Warn the patient against driving or operating machinery.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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