Drug interactions
Lofexidine + Nitroglycerin po
Severity: Moderate
Lofexidine and Nitroglycerin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin causes venodilation and arterial dilation, and lofexidine lowers blood pressure and heart rate. Together they may cause pronounced hypotension, dizziness and syncope.
What this interaction means in plain words
Lofexidine and Nitroglycerin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect from nitrate-mediated vasodilation and central alpha-2 sympatholysis.
What to do
Monitor blood pressure and heart rate, and advise patients to rise slowly. Reduce the dose of either drug if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Nitroglycerin po?
MediHelp rates the interaction as moderate. Lofexidine and Nitroglycerin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin causes venodilation and arterial dilation, and lofexidine lowers blood pressure and heart rate. Together they may cause pronounced hypotension, dizziness and syncope.
How serious is the interaction between Lofexidine and Nitroglycerin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and advise patients to rise slowly. Reduce the dose of either drug if symptomatic hypotension occurs.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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