Drug interactions
Lofexidine + Olmesartan
Severity: Moderate
Lofexidine and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and lofexidine also slows heart rate. Taken together they can cause additive hypotension, dizziness, syncope and bradycardia, particularly when lofexidine is started or the dose is raised.
What this interaction means in plain words
Lofexidine and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Olmesartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering from angiotensin receptor blockade plus central alpha-2 agonism with sympatholytic bradycardic effects.
What to do
Monitor blood pressure and pulse during lofexidine initiation and dose changes, and counsel the patient about orthostatic symptoms. Reduce the dose of one agent or hold the antihypertensive if symptomatic hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lofexidine and Olmesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Olmesartan?
MediHelp rates the interaction as moderate. Lofexidine and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and lofexidine also slows heart rate. Taken together they can cause additive hypotension, dizziness, syncope and bradycardia, particularly when lofexidine is started or the dose is raised.
How serious is the interaction between Lofexidine and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse during lofexidine initiation and dose changes, and counsel the patient about orthostatic symptoms. Reduce the dose of one agent or hold the antihypertensive if symptomatic hypotension or bradycardia develops.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
