Drug interactions
Lofexidine + Opium tincture
Severity: Moderate
Lofexidine and Opium tincture: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture contains morphine and causes opioid-related sedation and respiratory depression. Lofexidine adds drowsiness and hypotension, so the combination can increase CNS depression. Lofexidine is used in opioid withdrawal, so co-use occurs in practice during tapering.
What this interaction means in plain words
Lofexidine and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid receptor agonism and alpha-2 adrenergic agonism.
What to do
Monitor sedation, respiratory rate and blood pressure, especially at initiation and during dose changes. Reduce doses if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Opium tincture?
MediHelp rates the interaction as moderate. Lofexidine and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opium tincture contains morphine and causes opioid-related sedation and respiratory depression. Lofexidine adds drowsiness and hypotension, so the combination can increase CNS depression. Lofexidine is used in opioid withdrawal, so co-use occurs in practice during tapering.
How serious is the interaction between Lofexidine and Opium tincture?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and blood pressure, especially at initiation and during dose changes. Reduce doses if oversedation occurs.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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