Drug interactions
Lofexidine + Papaveretum
Severity: Moderate
Lofexidine and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine and produces sedation and respiratory depression. With lofexidine the CNS depressant and hypotensive effects may be additive.
What this interaction means in plain words
Lofexidine and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and alpha-2 adrenergic agonism.
What to do
Monitor sedation, respiratory rate and blood pressure, and start with lower opioid doses where possible. Avoid other sedatives at the same time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Papaveretum?
MediHelp rates the interaction as moderate. Lofexidine and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum contains opium alkaloids including morphine and produces sedation and respiratory depression. With lofexidine the CNS depressant and hypotensive effects may be additive.
How serious is the interaction between Lofexidine and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and blood pressure, and start with lower opioid doses where possible. Avoid other sedatives at the same time.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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