Drug interactions
Lofexidine + Pindolol
Severity: Moderate
Lofexidine and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents reduce heart rate and blood pressure, so combined use increases the risk of bradycardia and hypotension. Syncope or dizziness may occur, especially when lofexidine is started or doses are raised.
What this interaction means in plain words
Lofexidine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects of central alpha-2 agonism and beta-adrenergic blockade, although pindolol's intrinsic sympathomimetic activity may modestly blunt bradycardia.
What to do
Monitor pulse and blood pressure frequently during initiation and dose changes, and reduce or hold doses for symptomatic bradycardia or hypotension. Avoid in patients with significant baseline bradycardia or heart block.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lofexidine and Pindolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Pindolol?
MediHelp rates the interaction as moderate. Lofexidine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents reduce heart rate and blood pressure, so combined use increases the risk of bradycardia and hypotension. Syncope or dizziness may occur, especially when lofexidine is started or doses are raised.
How serious is the interaction between Lofexidine and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse and blood pressure frequently during initiation and dose changes, and reduce or hold doses for symptomatic bradycardia or hypotension. Avoid in patients with significant baseline bradycardia or heart block.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
