Drug interactions
Lofexidine + Quinapril
Severity: Moderate
Lofexidine and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers blood pressure and heart rate, and quinapril is an ACE inhibitor that also lowers blood pressure. Combined use can cause additive hypotension, particularly at initiation or in volume-depleted patients.
What this interaction means in plain words
Lofexidine and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive pharmacodynamic effects from central sympatholysis and inhibition of the renin-angiotensin system.
What to do
Monitor blood pressure and heart rate during initiation and dose changes, and counsel patients to rise slowly. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Quinapril?
MediHelp rates the interaction as moderate. Lofexidine and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers blood pressure and heart rate, and quinapril is an ACE inhibitor that also lowers blood pressure. Combined use can cause additive hypotension, particularly at initiation or in volume-depleted patients.
How serious is the interaction between Lofexidine and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and dose changes, and counsel patients to rise slowly. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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