Drug interactions
Lofexidine + Sacubitril / valsartan
Severity: Moderate
Lofexidine and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so concurrent use may cause additive hypotension, dizziness or syncope. Lofexidine can also slow the heart rate, adding to hemodynamic effects in patients with heart failure.
What this interaction means in plain words
Lofexidine and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from central alpha-2 agonism and angiotensin receptor blockade with neprilysin inhibition.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug, and check for orthostatic symptoms. Lower the dose of one agent if hypotension becomes symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lofexidine and Sacubitril / valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Lofexidine and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so concurrent use may cause additive hypotension, dizziness or syncope. Lofexidine can also slow the heart rate, adding to hemodynamic effects in patients with heart failure.
How serious is the interaction between Lofexidine and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug, and check for orthostatic symptoms. Lower the dose of one agent if hypotension becomes symptomatic.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
