Drug interactions
Lofexidine + Sodium nitroprusside
Severity: Moderate
Lofexidine and Sodium nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroprusside is a potent intravenous vasodilator and lofexidine lowers blood pressure and heart rate. Together they may cause profound hypotension and bradycardia.
What this interaction means in plain words
Lofexidine and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Sodium nitroprusside belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from nitric oxide mediated vasodilation and central alpha-2 sympatholysis.
What to do
Monitor blood pressure continuously during nitroprusside infusion and titrate to effect, with attention to heart rate in patients on lofexidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sodium nitroprusside
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Sodium nitroprusside?
MediHelp rates the interaction as moderate. Lofexidine and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroprusside is a potent intravenous vasodilator and lofexidine lowers blood pressure and heart rate. Together they may cause profound hypotension and bradycardia.
How serious is the interaction between Lofexidine and Sodium nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during nitroprusside infusion and titrate to effect, with attention to heart rate in patients on lofexidine.
What other medicines interact with Sodium nitroprusside?
MediHelp also lists interactions of Sodium nitroprusside with, for example, Avanafil, Nitric oxide, Sildenafil. The full list is on the Sodium nitroprusside page.
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