Drug interactions
Lofexidine + Telmisartan-amlodipine
Severity: Moderate
Lofexidine and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers blood pressure and heart rate, and telmisartan and amlodipine add antihypertensive effects. Together they can cause excessive hypotension, dizziness, syncope and bradycardia, especially during opioid withdrawal treatment.
What this interaction means in plain words
Lofexidine and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through central alpha-2 agonism (lofexidine) plus angiotensin receptor blockade and calcium channel blockade.
What to do
Monitor blood pressure and pulse before and after dosing, and counsel the patient to rise slowly. Reduce the antihypertensive dose or hold lofexidine doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Lofexidine and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers blood pressure and heart rate, and telmisartan and amlodipine add antihypertensive effects. Together they can cause excessive hypotension, dizziness, syncope and bradycardia, especially during opioid withdrawal treatment.
How serious is the interaction between Lofexidine and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse before and after dosing, and counsel the patient to rise slowly. Reduce the antihypertensive dose or hold lofexidine doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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