Drug interactions
Lofexidine + Triclofos
Severity: Moderate
Lofexidine and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic that is converted to trichloroethanol, and lofexidine also causes sedation. Together they may result in excessive drowsiness and a greater risk of falls or accidents.
What this interaction means in plain words
Lofexidine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and hypotension, and give the lowest effective triclofos dose. Advise against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Triclofos?
MediHelp rates the interaction as moderate. Lofexidine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic that is converted to trichloroethanol, and lofexidine also causes sedation. Together they may result in excessive drowsiness and a greater risk of falls or accidents.
How serious is the interaction between Lofexidine and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and hypotension, and give the lowest effective triclofos dose. Advise against driving and alcohol use.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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