Drug interactions
Lofexidine + Triprolidine
Severity: Moderate
Lofexidine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is an alpha-2 agonist that causes sedation, hypotension and bradycardia, and triprolidine can increase sedation further. This may impair alertness and raise the risk of dizziness and falls.
What this interaction means in plain words
Lofexidine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression.
What to do
Monitor sedation, blood pressure and heart rate, and advise the patient to avoid driving and other hazardous tasks. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Triprolidine?
MediHelp rates the interaction as moderate. Lofexidine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is an alpha-2 agonist that causes sedation, hypotension and bradycardia, and triprolidine can increase sedation further. This may impair alertness and raise the risk of dizziness and falls.
How serious is the interaction between Lofexidine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate, and advise the patient to avoid driving and other hazardous tasks. Consider a non-sedating antihistamine.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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