Drug interactions
Lofexidine + Yohimbine
Severity: Moderate
Lofexidine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 adrenergic antagonist and can directly oppose the effects of lofexidine, an alpha-2 agonist. This may reduce lofexidine's efficacy in controlling opioid withdrawal symptoms and may cause hypertension, tachycardia and anxiety.
What this interaction means in plain words
Lofexidine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at alpha-2 adrenergic receptors.
What to do
Avoid yohimbine in patients receiving lofexidine where possible. If used, monitor withdrawal symptoms, blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Yohimbine?
MediHelp rates the interaction as moderate. Lofexidine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 adrenergic antagonist and can directly oppose the effects of lofexidine, an alpha-2 agonist. This may reduce lofexidine's efficacy in controlling opioid withdrawal symptoms and may cause hypertension, tachycardia and anxiety.
How serious is the interaction between Lofexidine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbine in patients receiving lofexidine where possible. If used, monitor withdrawal symptoms, blood pressure and heart rate.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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