Drug interactions
Lonapegsomatropin + Metformin-repaglinide
Severity: Moderate
Lonapegsomatropin and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone products can reduce insulin sensitivity and raise blood glucose, particularly at higher doses, which may weaken the glucose-lowering effect of metformin and repaglinide. Growth hormone may also modestly increase CYP-mediated clearance of some drugs, which could lower repaglinide exposure.
What this interaction means in plain words
Lonapegsomatropin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonapegsomatropin belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through growth hormone-induced insulin resistance, with a possible minor increase in CYP3A4-mediated metabolism of repaglinide.
What to do
Monitor blood glucose and HbA1c after starting or changing the lonapegsomatropin dose, and increase the antidiabetic dose if glycemic control worsens. Reassess the regimen when growth hormone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Lonapegsomatropin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone products can reduce insulin sensitivity and raise blood glucose, particularly at higher doses, which may weaken the glucose-lowering effect of metformin and repaglinide. Growth hormone may also modestly increase CYP-mediated clearance of some drugs, which could lower repaglinide exposure.
How serious is the interaction between Lonapegsomatropin and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the lonapegsomatropin dose, and increase the antidiabetic dose if glycemic control worsens. Reassess the regimen when growth hormone is stopped.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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