Drug interactions
Lonapegsomatropin + Pirfenidone
Severity: Minor
Lonapegsomatropin and Pirfenidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP450 activity, including CYP1A2. This could lower pirfenidone concentrations and reduce its antifibrotic effect, though the clinical significance is uncertain.
What this interaction means in plain words
Lonapegsomatropin and Pirfenidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonapegsomatropin belongs to Endocrine; Pirfenidone belongs to Miscellaneous.
Why it happens
Growth hormone may induce CYP1A2, increasing pirfenidone clearance.
What to do
No routine adjustment is needed; monitor clinical response and lung function in pirfenidone-treated patients starting or stopping growth hormone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pirfenidone
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Pirfenidone?
MediHelp rates the interaction as minor. Lonapegsomatropin and Pirfenidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase CYP450 activity, including CYP1A2. This could lower pirfenidone concentrations and reduce its antifibrotic effect, though the clinical significance is uncertain.
How serious is the interaction between Lonapegsomatropin and Pirfenidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor clinical response and lung function in pirfenidone-treated patients starting or stopping growth hormone.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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