Drug interactions
Lonapegsomatropin + Prednisolone
Severity: Moderate
Lonapegsomatropin and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which activates cortisone to cortisol. Starting lonapegsomatropin may reduce cortisol activity and unmask adrenal insufficiency, and it can reduce the effect of prednisone, which requires activation. Prednisolone itself is already active, so the effect is less.
What this interaction means in plain words
Lonapegsomatropin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonapegsomatropin belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Growth hormone inhibits 11-beta-HSD1, reducing conversion of inactive to active glucocorticoids.
What to do
Monitor for adrenal insufficiency and review glucocorticoid dosing after starting growth hormone. Higher replacement doses may be needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Prednisolone?
MediHelp rates the interaction as moderate. Lonapegsomatropin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which activates cortisone to cortisol. Starting lonapegsomatropin may reduce cortisol activity and unmask adrenal insufficiency, and it can reduce the effect of prednisone, which requires activation. Prednisolone itself is already active, so the effect is less.
How serious is the interaction between Lonapegsomatropin and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adrenal insufficiency and review glucocorticoid dosing after starting growth hormone. Higher replacement doses may be needed.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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