Drug interactions
Lonapegsomatropin + Repaglinide
Severity: Moderate
Lonapegsomatropin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone analogs can reduce insulin sensitivity, especially at higher doses, which may weaken the glucose-lowering effect of repaglinide. Patients with diabetes may develop worsened glycemic control.
What this interaction means in plain words
Lonapegsomatropin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonapegsomatropin belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance, opposing the effect of repaglinide.
What to do
Monitor blood glucose regularly after starting or adjusting lonapegsomatropin. Increase the repaglinide dose or add other antihyperglycemic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Repaglinide?
MediHelp rates the interaction as moderate. Lonapegsomatropin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone analogs can reduce insulin sensitivity, especially at higher doses, which may weaken the glucose-lowering effect of repaglinide. Patients with diabetes may develop worsened glycemic control.
How serious is the interaction between Lonapegsomatropin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly after starting or adjusting lonapegsomatropin. Increase the repaglinide dose or add other antihyperglycemic therapy as needed.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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