Drug interactions
Loprazolam + Lorazepam
Severity: Moderate
Loprazolam and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so combined use gives additive sedation, impaired coordination and respiratory depression with no therapeutic benefit.
What this interaction means in plain words
Loprazolam and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor potentiation.
What to do
Avoid using two benzodiazepines together; if switching, taper one while starting the other and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Loprazolam with Lorazepam?
MediHelp rates the interaction as moderate. Loprazolam and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are benzodiazepines, so combined use gives additive sedation, impaired coordination and respiratory depression with no therapeutic benefit.
How serious is the interaction between Loprazolam and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two benzodiazepines together; if switching, taper one while starting the other and monitor for oversedation.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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