Drug interactions
Lorazepam + Lormetazepam
Severity: Moderate
Lorazepam and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so taking them together adds to sedation, psychomotor impairment and the risk of respiratory depression. The combination offers no therapeutic advantage and raises the chance of falls and next-day impairment, especially in older adults.
What this interaction means in plain words
Lorazepam and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive enhancement of GABA-A receptor mediated CNS inhibition.
What to do
Avoid using two benzodiazepines together; consolidate to a single agent at the lowest effective dose. If overlap is unavoidable, monitor sedation and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Lormetazepam?
MediHelp rates the interaction as moderate. Lorazepam and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are benzodiazepines, so taking them together adds to sedation, psychomotor impairment and the risk of respiratory depression. The combination offers no therapeutic advantage and raises the chance of falls and next-day impairment, especially in older adults.
How serious is the interaction between Lorazepam and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two benzodiazepines together; consolidate to a single agent at the lowest effective dose. If overlap is unavoidable, monitor sedation and respiratory status.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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