Drug interactions
Lorazepam + Loxapine inhaled
Severity: Major
Lorazepam and Loxapine inhaled: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine can cause bronchospasm and sedation, and benzodiazepines add CNS and respiratory depression. Hypotension may also be additive. Labeling notes that concurrent benzodiazepine use warrants caution.
What this interaction means in plain words
Lorazepam and Loxapine inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depressant effects of a benzodiazepine and an antipsychotic, with possible additive hypotension.
What to do
Monitor respiratory rate, oxygen saturation, blood pressure and sedation after dosing. Avoid giving close together in patients with airway disease or compromised respiration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Loxapine inhaled?
MediHelp rates the interaction as major. Lorazepam and Loxapine inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inhaled loxapine can cause bronchospasm and sedation, and benzodiazepines add CNS and respiratory depression. Hypotension may also be additive. Labeling notes that concurrent benzodiazepine use warrants caution.
How serious is the interaction between Lorazepam and Loxapine inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, oxygen saturation, blood pressure and sedation after dosing. Avoid giving close together in patients with airway disease or compromised respiration.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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