Drug interactions
Lorazepam + Marijuana
Severity: Moderate
Lorazepam and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can intensify the sedation, dizziness and cognitive and psychomotor impairment produced by lorazepam. Combined use raises the risk of falls, accidents and impaired judgment.
What this interaction means in plain words
Lorazepam and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via cannabinoid receptor effects and GABAergic enhancement.
What to do
Counsel patients to avoid cannabis while taking lorazepam and to avoid driving or hazardous tasks. Reduce the benzodiazepine dose if use cannot be stopped and sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Marijuana?
MediHelp rates the interaction as moderate. Lorazepam and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can intensify the sedation, dizziness and cognitive and psychomotor impairment produced by lorazepam. Combined use raises the risk of falls, accidents and impaired judgment.
How serious is the interaction between Lorazepam and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid cannabis while taking lorazepam and to avoid driving or hazardous tasks. Reduce the benzodiazepine dose if use cannot be stopped and sedation is excessive.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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