Drug interactions
Lorazepam + Meprobamate
Severity: Moderate
Lorazepam and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic, and combining it with a benzodiazepine increases drowsiness, impaired coordination and respiratory depression. Overdose risk is higher when both are taken together.
What this interaction means in plain words
Lorazepam and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through overlapping GABAergic sedative effects.
What to do
Avoid routine co-prescription of two anxiolytic-sedatives. If both are needed, use the lowest doses and monitor sedation and breathing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Meprobamate?
MediHelp rates the interaction as moderate. Lorazepam and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic, and combining it with a benzodiazepine increases drowsiness, impaired coordination and respiratory depression. Overdose risk is higher when both are taken together.
How serious is the interaction between Lorazepam and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-prescription of two anxiolytic-sedatives. If both are needed, use the lowest doses and monitor sedation and breathing.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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