Drug interactions
Lorazepam + Metoclopramide intranasal
Severity: Moderate
Lorazepam and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause sedation, drowsiness and extrapyramidal effects, and CNS depressants may add to these effects. The combination may increase somnolence and psychomotor impairment.
What this interaction means in plain words
Lorazepam and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; metoclopramide central dopamine antagonism adds to benzodiazepine sedation.
What to do
Monitor for excessive sedation and extrapyramidal symptoms. Counsel patients against driving or operating machinery and reduce doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Lorazepam and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause sedation, drowsiness and extrapyramidal effects, and CNS depressants may add to these effects. The combination may increase somnolence and psychomotor impairment.
How serious is the interaction between Lorazepam and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and extrapyramidal symptoms. Counsel patients against driving or operating machinery and reduce doses if needed.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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