Drug interactions
Lorazepam + Moxonidine
Severity: Moderate
Lorazepam and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that can cause sedation and drowsiness, and lorazepam may add to these effects. Dizziness and low blood pressure may also be more pronounced. The labeling for moxonidine advises that benzodiazepines may increase sedation.
What this interaction means in plain words
Lorazepam and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; moxonidine acts on central imidazoline and alpha-2 receptors while lorazepam enhances GABA-A activity.
What to do
Monitor for excessive sedation and orthostatic hypotension, particularly at initiation and dose changes. Lower the dose of one or both drugs if drowsiness impairs function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Moxonidine?
MediHelp rates the interaction as moderate. Lorazepam and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive that can cause sedation and drowsiness, and lorazepam may add to these effects. Dizziness and low blood pressure may also be more pronounced. The labeling for moxonidine advises that benzodiazepines may increase sedation.
How serious is the interaction between Lorazepam and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and orthostatic hypotension, particularly at initiation and dose changes. Lower the dose of one or both drugs if drowsiness impairs function.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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