Drug interactions
Lorazepam + Orphenadrine
Severity: Moderate
Lorazepam and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness and dizziness, and lorazepam can intensify these effects. Confusion and falls are a particular concern in older patients.
What this interaction means in plain words
Lorazepam and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABAergic enhancement and central anticholinergic activity.
What to do
Monitor for oversedation and confusion and use the lowest effective doses. Avoid the combination in older adults where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Orphenadrine?
MediHelp rates the interaction as moderate. Lorazepam and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness and dizziness, and lorazepam can intensify these effects. Confusion and falls are a particular concern in older patients.
How serious is the interaction between Lorazepam and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and confusion and use the lowest effective doses. Avoid the combination in older adults where possible.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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