Drug interactions
Lorazepam + Pimozide
Severity: Moderate
Lorazepam and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use can cause additive drowsiness and impaired coordination. Lorazepam does not meaningfully affect pimozide metabolism, so the main concern is CNS depression rather than QT effects.
What this interaction means in plain words
Lorazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and central dopamine blockade.
What to do
Monitor for oversedation and impaired function, and counsel against driving. Keep doses as low as clinically effective.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Lorazepam with Pimozide?
MediHelp rates the interaction as moderate. Lorazepam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use can cause additive drowsiness and impaired coordination. Lorazepam does not meaningfully affect pimozide metabolism, so the main concern is CNS depression rather than QT effects.
How serious is the interaction between Lorazepam and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and impaired function, and counsel against driving. Keep doses as low as clinically effective.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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