Drug interactions
Lorazepam + Protriptyline
Severity: Moderate
Lorazepam and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants and benzodiazepines can add to sedation, psychomotor impairment and anticholinergic cognitive effects. Protriptyline is less sedating than many tricyclics, so the effect is usually modest but still relevant in older patients.
What this interaction means in plain words
Lorazepam and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A enhancement and the antihistaminic and anticholinergic effects of the tricyclic.
What to do
Monitor for drowsiness, confusion and falls, and adjust doses as needed. Prefer lower doses in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Protriptyline?
MediHelp rates the interaction as moderate. Lorazepam and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants and benzodiazepines can add to sedation, psychomotor impairment and anticholinergic cognitive effects. Protriptyline is less sedating than many tricyclics, so the effect is usually modest but still relevant in older patients.
How serious is the interaction between Lorazepam and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness, confusion and falls, and adjust doses as needed. Prefer lower doses in older adults.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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