Drug interactions
Lorazepam + Remimazolam
Severity: Major
Lorazepam and Remimazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is an ultra-short-acting benzodiazepine, and adding lorazepam increases sedative and respiratory depressant effects. Profound sedation, hypoventilation and hypoxia can occur.
What this interaction means in plain words
Lorazepam and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lorazepam belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor mediated CNS and respiratory depression.
What to do
Titrate remimazolam carefully with reduced doses and continuously monitor oxygenation, ventilation and vital signs through recovery. Ensure airway support and a reversal agent (flumazenil) are available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lorazepam
Other interactions of Remimazolam
Frequently asked questions
Can I take Lorazepam with Remimazolam?
MediHelp rates the interaction as major. Lorazepam and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Remimazolam is an ultra-short-acting benzodiazepine, and adding lorazepam increases sedative and respiratory depressant effects. Profound sedation, hypoventilation and hypoxia can occur.
How serious is the interaction between Lorazepam and Remimazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully with reduced doses and continuously monitor oxygenation, ventilation and vital signs through recovery. Ensure airway support and a reversal agent (flumazenil) are available.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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