Drug interactions
Lorazepam + Thiothixene
Severity: Moderate
Lorazepam and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is a sedating antipsychotic and adds to the sedative and psychomotor effects of lorazepam. Hypotension, drowsiness and impaired coordination may be more pronounced.
What this interaction means in plain words
Lorazepam and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from GABA-A potentiation plus antihistaminic and antiadrenergic effects of the antipsychotic.
What to do
Monitor sedation and blood pressure, particularly when starting or increasing doses, and lower doses in elderly patients. Advise against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Thiothixene?
MediHelp rates the interaction as moderate. Lorazepam and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is a sedating antipsychotic and adds to the sedative and psychomotor effects of lorazepam. Hypotension, drowsiness and impaired coordination may be more pronounced.
How serious is the interaction between Lorazepam and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, particularly when starting or increasing doses, and lower doses in elderly patients. Advise against driving and alcohol use.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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