Drug interactions
Lorazepam + Trifluoperazine
Severity: Moderate
Lorazepam and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine, a phenothiazine antipsychotic, can add to the sedation and psychomotor impairment caused by lorazepam. Additive hypotension and impaired alertness may occur.
What this interaction means in plain words
Lorazepam and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression through GABA-A potentiation and antipsychotic receptor blockade.
What to do
Monitor for oversedation and hypotension, and reduce doses if needed, especially in older patients. Advise patients to avoid alcohol and driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Trifluoperazine?
MediHelp rates the interaction as moderate. Lorazepam and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine, a phenothiazine antipsychotic, can add to the sedation and psychomotor impairment caused by lorazepam. Additive hypotension and impaired alertness may occur.
How serious is the interaction between Lorazepam and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and hypotension, and reduce doses if needed, especially in older patients. Advise patients to avoid alcohol and driving until tolerance is established.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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