Drug interactions
Lorazepam + Triprolidine
Severity: Moderate
Lorazepam and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A sedating antihistamine taken with a benzodiazepine increases drowsiness, slows reaction time and impairs memory and coordination. Older patients are at particular risk of falls and confusion.
What this interaction means in plain words
Lorazepam and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression through histaminergic blockade and GABA-A potentiation.
What to do
Avoid combining where possible, and monitor sedation and psychomotor function if both are needed. Use a non-sedating antihistamine as an alternative and advise against alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lorazepam and Triprolidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Triprolidine
Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Triprolidine?
MediHelp rates the interaction as moderate. Lorazepam and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A sedating antihistamine taken with a benzodiazepine increases drowsiness, slows reaction time and impairs memory and coordination. Older patients are at particular risk of falls and confusion.
How serious is the interaction between Lorazepam and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, and monitor sedation and psychomotor function if both are needed. Use a non-sedating antihistamine as an alternative and advise against alcohol.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
