Drug interactions
Lorazepam + Yohimbine
Severity: Minor
Lorazepam and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects that may oppose the sedative and anxiolytic effects of lorazepam. The result is unpredictable and clinical evidence is limited.
What this interaction means in plain words
Lorazepam and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism between noradrenergic stimulation from yohimbine and GABAergic inhibition from lorazepam; not well characterized.
What to do
Monitor for reduced lorazepam effect or anxiety and agitation, and adjust therapy based on response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Lorazepam with Yohimbine?
MediHelp rates the interaction as minor. Lorazepam and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects that may oppose the sedative and anxiolytic effects of lorazepam. The result is unpredictable and clinical evidence is limited.
How serious is the interaction between Lorazepam and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced lorazepam effect or anxiety and agitation, and adjust therapy based on response.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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