Drug interactions
Lorazepam + Zolpidem
Severity: Moderate
Lorazepam and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zolpidem with lorazepam increases sedation and impairs psychomotor function and memory. Risk of falls, complex sleep behaviors and respiratory depression is increased, especially in older adults.
What this interaction means in plain words
Lorazepam and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive enhancement of GABA-A receptor mediated CNS depression.
What to do
Avoid concurrent use where possible; otherwise use the lowest doses and monitor for oversedation and respiratory depression. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Zolpidem
Frequently asked questions
Can I take Lorazepam with Zolpidem?
MediHelp rates the interaction as moderate. Lorazepam and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zolpidem with lorazepam increases sedation and impairs psychomotor function and memory. Risk of falls, complex sleep behaviors and respiratory depression is increased, especially in older adults.
How serious is the interaction between Lorazepam and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; otherwise use the lowest doses and monitor for oversedation and respiratory depression. Advise against driving and alcohol.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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