Drug interactions
Lorcaserin + Phenelzine
Severity: Contraindicated
Lorcaserin and Phenelzine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist. Together with an MAOI there is a risk of serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability.
What this interaction means in plain words
Lorcaserin and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive serotonergic activity: receptor agonism plus MAO-blocked serotonin breakdown.
What to do
Do not combine; use another weight-management option. Allow a washout of at least 14 days after stopping phenelzine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Lorcaserin with Phenelzine?
MediHelp rates the interaction as contraindicated. Lorcaserin and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lorcaserin is a serotonin 5-HT2C agonist. Together with an MAOI there is a risk of serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability.
How serious is the interaction between Lorcaserin and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use another weight-management option. Allow a washout of at least 14 days after stopping phenelzine.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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